Effect of quetiapine on arterial oxygen saturation on head trauma patients

Abstract

Background: Traumatic brain injury (TBI) is considered a major global public health epidemic, economic and social issue as it is the main cause of death and disability in most countries.Aim and objectives: To assess and evaluate the efficacy and safety of Quetiapine in the management of agitated behaviors following traumatic brain injury (TBI) and its effect on arterial oxygen saturationPatient and methods: This prospective randomized controlled study conducted on 40 adult patients (divided into 2 equal groups, 20 cases each) aged 18-60 years old with isolated moderate TBI in trauma ICU of Minia University Hospital (MUH) starting from July 15, 2022.Results: There was a substantial variation between the two studied groups as regard arterial oxygen saturation readings which was significantly higher in group Q compared to group C in the 7th and 8th days.Conclusion: Quetiapine was safe and effective in the management of agitated behaviors following traumatic brain injury (TBI) and improvement of arterial oxygen saturation.