article · International Dental Journal
The aim of this study was to evaluate the possible regenerative effect of bone marrow mesenchymal stem cells (BMSCs) over time on damaged salivary glands through systemic injections. 38 male Albino rats were randomly divided into 4 groups: Group 1: 10 rats received 0.5 ml of phosphate-buffered saline (PBS) by injection. Group 2: 14 rats received an intraperitoneal injection of 5-Fluorouracil (5-FU) anti-cancerous drug. Group 3: 14 rats were injected the same dose of 5-FU then received an intravenous injection of BMSCs suspended in 0.5 ml of PBS via the tail vein at day 1 after 5-FU administration. Five rats of group 1 and seven rats of each of groups 2 and 3 were sacrificed at days 6 and 10 after 5-FU or PBS administration. Histological examination showed that group 2 showed features of severe degenerative changes which increased over time. Group 3 showed increasing amelioration in the ductal structure overtime. Imunohistochemical results revealed improvement in group 3. CONCLUSION(S) Histological and immunohistochemical features revealed statistically significant amelioration in regenerative potentials of group 3 compared to group 1.
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DOI: 10.1016/j.identj.2024.07.164
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