Effect of Locally Delivered Spirulina Gel on the Treatment of Stage II, Grade B Periodontitis: A Randomized Control Clinical Study.

Abstract

Background and Aim: a potent antioxidant and anti-inflammatory can offer improved results in periodontitis cases. The current study set out to evaluate the clinical and immunological effects of spirulina gel as a scaling and root planing adjuvant for stage II, grade B periodontitis.Methods: Two groups of forty patients with stage II, grade B periodontitis were created. Group I (control group) (n = 20) received SRP with placebo gel in the pocket. Group II (spirulina group) (n = 20) received treatment with both spirulina gel and scaling and root planing (SRP). Plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing pocket depth (PPD) were the clinical parameters that were measured at baseline, one, three, and six months following therapy. Using an enzyme-linked immunological test, the levels of interleukin 6 (IL-6) in gingival crevicular fluid were measured at baseline, 1, 3, and 6 months following treatment. Results: Both groups' clinical and biochemical markers significantly improved. In comparison to the control group, the spirulina group had statistically significant improvements in clinical PPD, CAL, and IL-6 at 1, 3, and 6 months following therapy.Conclusions: Local drug delivery of spirulina gel adjunctive to SRP has potent anti-inflammatory in treatment of stage II, grade B periodontitis. Spirulina is promising treatment of periodontitis.