Effect of Human Amniotic Membrane Application on Microskin Graft

Abstract

Background; Severe full-thickness burns and significant injuries that cause extensive skin damage hinder natural regeneration and jeopardize patient survival. Immediate coverage is essential to restore normal skin function. When a donor site is available, using an autograft is always the preferred and most effective option. Aim and objectives; To assess the impact of applying human amniotic membrane at the recipient site of micro-autogenous split-thickness skin grafts for covering post-burn raw areas, this study focuses on several factors: the graft take percentage, infection rates, time required for complete wound healing, the expansion ratio of the recipient site to the graft donor site, and the scar evaluation of the graft. Subjects and methods; This prospective controlled clinical study was conducted on 20 patients at the Plastic Surgery Department of Minia University Hospitals. The study involved applying human amniotic membrane to the recipient site of micro-autogenous split-thickness skin grafts on only one half of the raw area, with the other half serving as a control. Results; The mean time for complete healing in study side which is covered by amniotic membrane is (25.5±4.2), and it is significantly lower than the control side which is not covered by amniotic membrane which is (30.8±5). No need for another session of grafting at both sides.