article · Minia Journal of Medical Research
Background : Diabetes mellitus (DM) is a chronic metabolic condition defined by persistent hyperglycemia . Parkinsonism is a clinical syndrome with bradykinesia, static tremors, rigidity, and postural instability. Parkinson's disease is a neurological condition that progresses progressively over time. As people age, it becomes more common. Clinical symptoms remain the primary determinant of PD diagnosis. Aim and Objectives: This study aims to detect the effect of diabetes mellitus on model of Parkinson's disease (PD) in adult albino rats. Material and Methods: This study was a prospective controlled experiment done in the laboratory of the Medical Physiology department, under the college of Medicine at Minia University. The experiment involved a collective of 30 rats. Results: The diabetic Parkinson's group exhibited a statistically significant deterioration in Malondialdehyde (MDA) , Total antioxidant capacity (TAC), and Tumor necrosis factor-alpha (TNF-α) compared to the control group (C group), Parkinson's group (P group), and Diabetes Parkinson's group (DP group). Conclusion: Diabetes mellitus has a worsening effect on Parkinson’s disease.
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DOI: 10.21608/mjmr.2024.277030.1691
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