Effect of central dialysis fluid delivery system using high flux dialyzer versus regular water treatment stations on endotoxemia and inflammatory markers among prevalent patients on regular hemodialysis

Abstract

<b>Purpose:</b> In this study, we compared the effects of a single patient dialysis fluid delivery system (SPDDS) against a central dialysis fluid delivery system (CDDS) on inflammatory markers and endotoxemia in a population of patients receiving routine hemodialysis (HD).<br /> <b>Materials & methods: </b>80 prevalent HD patients, aged from 18 to 60 years old, who were clinically stable and receiving thrice weekly dialysis treatments via an arteriovenous fistula were the subjects of a cross-sectional research. group I underwent HD using a CDDS water purification system that was implemented at El Demerdash Hospital two years prior, and group II underwent HD using an SPDDS water purification system at Ain Shams Specialized Hospital.<br /> <b>Results: </b>Pre-dialysis endotoxin levels were significantly lower in the CDDS group (0.07±0.05) compared to the SPDDS group (0.20±0.07), p-value<0.001, post-dialysis serum endotoxin levels were significantly lower in CDDS group (0.04±0.02) compared to SDDPS (0.15±0.03), p-value<0.001.<br /> <b>Conclusions:</b> CDDS group’s circulating endotoxins had significantly decreased.