article · Annals of Epidemiology

Early adherence predicts treatment outcomes and mortality in people living with HIV and multidrug-resistant tuberculosis

Kevin Guzman
Matthew J. Cummings
Boitumelo Seepamore
Xuan Lu
Resha Boodhram
Karl Reis
Allison Wolf
Ying Kuen Cheung
Nesri Padayatchi
Kogieleum Naidoo
Jennifer Zelnick
Amrita Daftary
K Rivet Amico
Gerald Friedland
Rubeshan Perumal
Max R. O’Donnell

2026Open accessUniversity of KwaZulu-Natal

Abstract

Adherence in the first four weeks of bedaquiline therapy provides a powerful, early signal of treatment outcomes. Real-time adherence monitoring could enable risk stratification and tailored interventions to improve RR/MDR-TB and HIV care.

Research topics

HIV/AIDS Research and Interventions
Tuberculosis Research and Epidemiology
HIV-related health complications and treatments

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1016/j.annepidem.2026.110082

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