article · Future Medicinal Chemistry

Dual VEGFR-2 and EGFR <sup>T790M</sup> inhibitors of phenyldiazenes: anticancer evaluations, ADMET, docking, design and synthesis

Marwa Alsulaimany
Adel H. Al‐Shareef
Omar M. Alatawi
Hussam Y. Alharbi
Khaled El‐Adl
Ahmed K. B. Aljohani
Nour E. A. Abd El‐Sattar
Majed S. Aljohani
Sara A. Almadani
Doaa E. Keshek
Read Alghamdi
Saeed M Tayeb
Kurls E. Anwer

202511 citationsOpen accessHeliopolis University

Abstract

AIM: New phenyldiazene scaffold-linked heterocyclic pyrazole, pyrimidinone, pyrimidinthione, and/or triazine rings have been developed and synthesized. METHODS & RESULTS: showed good ADMET profile. CONCLUSION: inhibition.

Research topics

Click Chemistry and Applications
Synthesis and Characterization of Heterocyclic Compounds
Synthesis and biological activity

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1080/17568919.2025.2453409

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