Dual-targeting sepsis-associated inflammation and infection using linoleic acid-based lipid–polymer hybrid nanoparticles

Abstract

antibacterial performance compared to bare VCM, along with significant antioxidant and anti-inflammatory activity, in LPS-stimulated macrophages. In a murine MRSA-induced sepsis model, treatment with VCM-LIN-P2O NPs resulted in marked bacterial clearance from major organs and the bloodstream, accompanied by a significant reduction in TNF-α, IL-1β, and IL-18 levels, thereby alleviating organ damage. Therefore, these findings establish VCM-LIN-P2O NPs as a promising multifunctional nanoplatform for targeted antibiotic delivery and effective sepsis therapy.