Down-regulation of Long Non-coding RNA H19 and ADCK4 gene in Children with Nephrotic Syndrome

Abstract

<title>Abstract</title> <bold>AIM OF THE WORK:</bold> The objective of this study is to examine the correlation between the long non-coding RNA H19 and ADCK4 genes and the susceptibility to nephrotic syndrome in children from Egypt. <bold>METHODS:</bold> A cross-sectional research was conducted on 50 cases with nephrotic syndrome and 50 controls of apparently healthy children with no past or family history of renal or chronic diseases. Each participant signed their informed consent form. The study excluded malignancy, chronic infectious disorders, drug-induced membranous glomerulonephritis (MGN) or lupus nephritis. <bold>RESULTS:</bold> There was a significant divergence among cases and control regarding RQ (ADCK4) (p-value &lt; 0.001) and RQ (H-19) (p-value &lt; 0.001). Nevertheless, no notable distinction was observed between the two forms of nephrotic syndrome in terms of RQ (ADCK4) (p-value =0.935) and RQ (H-19) (p-value 0.525). <bold>CONCLUSION:</bold>In nephrotic syndrome, the RNA H19 and ADCK4 genes are downregulated, with no notable distinction observed between the steroid-sensitive and steroid-resistant patient groups.