article · Cancer Medicine

Differential Effects of Saturated and Unsaturated Fatty Acids on Colorectal Cancer via <scp>IDO1</scp> Signaling

Shulin Zhang
Jiaqi Chen
Hongbo Wang
Junhua Sun
Peiyao Li
Jiaxuan Li
Jing Zhang
Guang Yang
Di Zhao
Songlin Wu
Guanying Yu
Yanfeng Iv
Lin Yuan
Guimei Lin
Lifen Gao
Rola M. Labib
Lan Ye

2026Open accessAin Shams University

Abstract

These findings suggest that saturated fatty acids, particularly PA, may exacerbate CRC development risk through metabolic dysregulation, highlighting the potential of IDO1 as a biomarker for CRC associated with HFD. Reducing dietary saturated fat intake may thus be a viable strategy for CRC prevention.

Research topics

Fatty Acid Research and Health
Cancer, Lipids, and Metabolism
Coconut Research and Applications

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DOI: 10.1002/cam4.71644

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