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article · Journal of Advanced Research

Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense

2026Open accessCairo University

Abstract

Together, these findings suggest that dietary bioactive compounds modulate metabolic and gene regulatory processes, with functional evidence supporting a role for amino acid metabolism and lactate in linking metabolic remodeling to enhanced resistance to infection in the offspring. This work provides mechanistic insight into how diet can shape heritable immune function through metabolic-epigenetic interplay.

Research topics

  • Invertebrate Immune Response Mechanisms
  • Insect Utilization and Effects
  • Genetics, Aging, and Longevity in Model Organisms

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DOI: 10.1016/j.jare.2026.04.028

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