article · British Journal of Clinical Pharmacology

Determinants of early change in serum creatinine after initiation of dolutegravir‐based antiretroviral therapy in South Africa

Rephaim Mpofu
Simiso Sokhela
François Venter
David W. Haas
Gary Maartens
Lubbe Wiesner
Godspower Akpomiemie
Paolo Denti
Frank A. Post
Nomathemba Chandiwana
Aida N. Kawuma
Roeland E. Wasmann
Michelle Moorhouse
Phumla Sinxadi

20244 citationsOpen accessUniversity of the Witwatersrand

Abstract

Multiple clinical and pharmacokinetic factors were associated with early change in serum creatinine in individuals initiating dolutegravir-based ART. UGT1A1 polymorphisms may play a role, but further research on genetic determinants is needed.

Research topics

HIV/AIDS drug development and treatment
HIV-related health complications and treatments
Pneumocystis jirovecii pneumonia detection and treatment

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1111/bcp.16009

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