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article · Frontiers in Public Health

Determinants of CD4 count recovery among severely immunosuppressed HIV patients initiated on antiretroviral therapy: a prospective cohort study in KwaZulu-Natal, South Africa

Abstract

Delayed CD4 recovery among males, urban residents, TB-coinfected participants, and those with unsuppressed viral load (>400 copies/mL) underscores the need for targeted, differentiated HIV care strategies to accelerate immunological recovery and reduce HIV-related morbidity. Policymakers should prioritise male-focused interventions, strengthened TB-HIV integrated services, intensified adherence and viral load monitoring, and context-specific interventions in urban settings to accelerate immunological recovery and reduce HIV-related morbidity.

Research topics

  • HIV Research and Treatment
  • HIV/AIDS Research and Interventions
  • Pneumocystis jirovecii pneumonia detection and treatment

Sustainable Development Goals

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DOI: 10.3389/fpubh.2026.1766369

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