article · Drug Design Development and Therapy
The enzyme inhibitory test of compound <b>5p</b> showed that it is the most potent hybrid that caused MCF-7 cells to undergo apoptosis and generated a G1/S cell cycle arrest. Confirmation of the obtained results was done with the aid of the docking study, which showed that the three motifs might adhere to the enzyme's major active sites, and the results were in good accordance with the experimental VEGFR-2 inhibitory results. We can conclude that the new quinazoline compounds <b>5a-r</b> could be used as candidates for development of more efficient anticancer inhibitors.
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DOI: 10.2147/dddt.s490930
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