article · RSC Advances

Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive <i>in vitro</i> and <i>in silico</i> study

Ibrahim H. Eissa
Walid E. Elgammal
Hazem Elkady
Maymounah N. Alharthi
Simone Carradori
Eslam B. Elkaeed
Dalal Z. Husein
Hazem A. Mahdy
Ibrahim M. Ibrahim
Susi Zara
Ahmed M. Metwaly

202417 citationsOpen accessSouth Valley University

Abstract

Compound 20b presents as a promising anti-proliferative agent targeting VEGFR-2. Also, this comprehensive investigation underscores the potential of 2,3-dihydro-1,3,4-thiadiazole derivatives as promising candidates for further development in anti-cancer research.

Research topics

Angiogenesis and VEGF in Cancer
Synthesis and biological activity
HER2/EGFR in Cancer Research

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DOI: 10.1039/d4ra04158e

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