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article · RSC Medicinal Chemistry

Design, synthesis and characterization of novel pyridazin-3-one derivatives: <i>in vitro</i> vasorelaxant activity and <i>in silico</i> insights into eNOS modulation

20251 citationOpen accessSinai University

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Abstract

Two novel series of pyridazin-3-ones, designed as potential vasodilators, demonstrated superior aortic vasorelaxant activity, eNOS mRNA expression and nitric oxide up-levelling.

Research topics

  • Synthesis and Catalytic Reactions
  • Nitric Oxide and Endothelin Effects
  • Organic Chemistry Cycloaddition Reactions

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DOI: 10.1039/d4md00998c

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