article · RSC Advances

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives as novel anti-cancer, dual EGFR<sup>WT</sup>/COX-2 inhibitors with docking studies

202313 citationsOpen accessMisr University for Science and Technology

Abstract

/COX-2 inhibitors; erlotinib, and celecoxib, respectively. Finally, the physicochemical parameter was calculated for the most potent novel anticancer candidates and the SwissAdme parameter showed that the newly synthesized compounds have good drug-likeness properties.

Research topics

Synthesis and biological activity
Cancer therapeutics and mechanisms
Computational Drug Discovery Methods

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DOI: 10.1039/d3ra06088h

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