article · International Journal of Science and Research Archive
Ten novel metal complexes using an amido-salicylaldehyde ligand were synthesised and structurally evaluated with analytical and spectroscopic techniques. The metal ions examined included iron, manganese, cobalt, nickel, copper, cadmium, magnesium, aluminium, zinc, and barium. Structural analysis revealed that the ligand acts as a neutral or dibasic pentadentate donor, binding through imino nitrogen, hydroxyl oxygen, and amide oxygen atoms to form distorted octahedral geometries. Conductivity assessments established that the complexes exhibit non-electrolytic properties, while electron spin resonance spectroscopy provided specific electronic profiles for copper, iron, cobalt, and manganese complexes. In biological evaluations against MCF-7 breast cancer cells, coordination of the ligand to metals enhanced cytotoxic activity. The zinc complex displayed the highest potency relative to the reference drug vinblastine sulfate. Furthermore, molecular docking studies confirmed favourable binding interactions that align with the experimental cell culture results.
Cancer therapies often require new molecules capable of eliminating malignant cells effectively. By showing that binding a specific organic ligand to metal ions increases cytotoxicity against breast cancer cells, this work demonstrates the potential of coordination chemistry for oncology drug discovery. The marked potency of the zinc complex offers a compelling avenue for developing new metal-based therapeutic candidates.
This research represents early-stage laboratory discovery of potential interest to pharmaceutical researchers and oncology drug development programmes. The metal complexes, particularly the zinc formulation, could serve as lead structures for developing new chemotherapeutic treatments. Because the findings are based entirely on in vitro cell assays and computational docking, the technology is at an early experimental stage and requires extensive preclinical testing, safety profiling, and in vivo validation before clinical translation is viable.
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Novel Fe(III), Mn(II), Co(II), Ni(II), Cu(II), Cd(II), Mg(II), Al(III), Zn(II), and Ba(II) complexes of an amido-salicylaldehyde ligand were synthesized and characterized by various analytical and spectroscopic techniques. The ligand coordinated as a neutral or dibasic pentadentate donor through imino nitrogen, hydroxyl oxygen, and amide oxygen atoms, forming distorted octahedral complexes. Conductivity measurements indicated non-electrolytic behavior. ESR studies revealed axial Cu(II) spectra with a dx2−y2 ground state, while Fe(III), Co(II), and Mn(II) complexes showed isotropic signals. Cytotoxicity studies against MCF-7 cells demonstrated enhanced activity after complexation, with the Zn(II) complex showing the highest potency compared with vinblastine sulfate. Molecular docking further supported the experimental cytotoxicity results through favorable binding interactions.
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DOI: 10.30574/ijsra.2026.20.2.1644
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