article · Bioorganic Chemistry

Design and synthesis of novel thiazolotriazole–sulfonamide hybrids tackling antimicrobial resistance: mechanistic insights into efflux pump inhibitor, gene downregulation, and machine-aided results

Hossam H. Elsayed
Mohamed Hagras
Mohamed Abdel Samee Gadallah
Mahmoud M. Abdelfattah
Heba M. Hesham
Hazem H. Elsayed
Maiy Youssef Jaballah
Eman Z. Elrazaz
Nasser S. M. Ismail

2026Al-Azhar University

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Research topics

Enzyme function and inhibition
Sulfur-Based Synthesis Techniques
Synthesis and biological activity

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DOI: 10.1016/j.bioorg.2026.110324

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