article · RSC Advances

Design and synthesis of novel 2-(2-(4-bromophenyl)quinolin-4-yl)-1,3,4-oxadiazole derivatives as anticancer and antimicrobial candidates: <i>in vitro</i> and <i>in silico</i> studies

Noha Ryad
Samy Selim
Soad K. Al Jaouni
Islam Zaki
Arwa Sultan Alqahtani
Mohamed S. Abdel‐Aziz
Ayman Abo Elmaaty
Mohammed S. Almuhayawi
Lina M. A. Abdel Ghany

202410 citationsOpen accessMisr University for Science and Technology

Abstract

. Compounds 17b, 17d and 17e displayed the most potent inhibitory activity, exhibiting 4-, 16- and 8-fold more activity, respectively, than the reference neomycin. Hence, we can conclude that the afforded compounds can be used as lead dual anticancer and antimicrobial candidates for future optimization.

Research topics

Synthesis and biological activity
Click Chemistry and Applications
Synthesis and Biological Evaluation

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DOI: 10.1039/d4ra06712f

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