article · ACS Omega

Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives <i>via</i> Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors

Hany M. Abd El‐Lateef
Islam Zaki
Lina M. A. Abdel Ghany
Mohamed S. Abdel‐Aziz
Ayman Abo Elmaaty
Noha Ryad

202328 citationsOpen accessMisr University for Science and Technology

Abstract

revealed high GIT absorption without passing the blood brain barrier. Finally, the conducted structure-activity relationship study assured the usefulness of the hydrazine moiety as a molecular hybrid for activity either in cyclic or opened form.

Research topics

Cancer therapeutics and mechanisms
Synthesis and biological activity
Bioactive Compounds and Antitumor Agents

Read the original research

This page summarises published work. The authoritative version sits with the publisher.

View on publisher site Record on OpenAlex

DOI: 10.1021/acsomega.3c01156

Is something wrong with this record? Report it or request removal.

Discussion

Discuss this research

Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.

No discussion yet. Open the first thread.

New to MARATTO™? Create a free account.