DESIGN A SINGLE SCREW EXTRUDER FOR POLYMER-BASED TISSUE ENGINEERING

Abstract

In the area of tissue engineering, single screw extrusion (SSE) has gained attention due to its versatility and efficiency in fabricating polymer-based scaffolds. Furthermore, advancements such as the implementation of extrusion techniques and the integration of bioactive agents have significantly expanded the capabilities of SSE. This study aims to investigate the configuration of a custom-designed plastic extrusion for tissue engineering, highlighting its potential in fabricating suture technology for various regenerative biomedical applications. Furthermore, the challenges and future perspectives in SSE technology are discussed, with a focus on the need for additional research to optimize processing parameters, enhance structure bioactivity, and facilitate clinical usage. SSE provides precise regulation of structure morphology, mechanical properties, and porosity, which are critical factors that influence cell behavior and tissue regeneration. Overall, SSE holds great promise as a scalable and cost-effective manufacturing technique for producing polymer-based structures with tailored properties, advancing the field of tissue engineering towards effective clinical solutions. The paper provides a comprehensive overview of a filament extruder production machine that is capable of manufacturing high-quality filament sutures (FS) using thermoplastic materials, specifically bio-protein derived from human serum albumin. The main focus of the paper is to explain the design and operation principles of the filament extruder. The extruder is equipped with a die that can measure a range starting from 2.5 mm and going down to smaller scales. This allows for the extrusion of filaments with a diameter as small as 1.75 mm. Although the design of the extrusion apparatus closely resembles that of commercially available machines, the focus here is on its adaptability and cost-effectiveness for laboratory-scale production. Overall, the research contributes to advancing the understanding of extrusion processing technologies in the context of biomedical applications, with a specific focus on utilizing human serum albumin-derived thermoplastics for manufacturing FS.