Descriptive study for recurrent idiopathic acute pancreatitis cases admitted in Kasr El-Ainy endoscopy unit

Abstract

Background: Acute pancreatitis (AP) defined as an acute inflammatory process of the pancreas that may also involve peripancreatic tissues and/or remote organ systems. It is the most common pancreatic disease worldwide and it is a serious medical condition, hence its overall mortality is approximately 5%.Most clinical management guidelines emphasize on identifying cause in the initial period as there is no specific drug available to treat this condition. Aim of the study: UP to10% to 30% of patients diagnosed as acute pancreatitis do not have a clear cause after routine investigations, The aim of the study is to determine the cause of pancreatitis in those patients also. Patients and Methods: We conducted a descriptive cross-sectional study on 80 patients with RIAP inpatients between 2023 and 2024. laboratory data, includes liver, renal, complete blood count and lipid assessed. Results: Hemoglobin levels averaged 12.1 ± 1.2 g/dL, total leukocyte count was 7.8 ± 2.3 ×10³/µL, and platelet count averaged 218.5 ± 57.2 ×10³/µL. Other findings included pancreatic duct stones (8.6%), Serum creatinine averaged 1.1 ± 0.3 mg/dL and urea 44.2 ± 12.5 mg/dL. Mean Na and K 137.6 ± 3.1 mEq/L Conclusion: The causes are extensive and include, but are not limited to, the following: autoimmune pancreatitis, hypertriglyceridemia, post-endoscopic retrograde cholangiopancreatography (ERCP), genetic risk (gain of function mutations in PRSS1), pancreatic duct injury and medications of of patients idiopathic cases.