article · PLoS ONE
The abstract on record is too brief for a reliable plain-language summary, so none has been generated.
The relative changes in plasma lactate concentration assessed at 8 or 12 hours after admission are valid surrogate endpoints for severe malaria studies on antimalarial drugs or adjuvant treatments aiming at improving the microcirculation. Measures of coma recovery are not valid surrogate endpoints for mortality.
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DOI: 10.1371/journal.pone.0169307
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