article · Recent Patents on Anti-Cancer Drug Discovery

Daidzein and Chicory Extract Arrest the Cell Cycle <i>via</i> Inhibition ofCyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in HepatocellularCarcinoma

Nabil Mohie Abdel‐Hamid
Sherin Zakaria
Ramadan A. El-Domany
Reem A. Nawaya
Mamdouh M. El‐Shishtawy

202211 citationsKafr el-Sheikh University

Abstract

Treatment with DAZ or CE alone, or in combination, could possess an inhibitory effect on hepatocarcinogenesis via cell cycle arrest, inhibition of proliferation through suppression of Ki-67 expression, and apoptosis induction, mediated by downregulation of Bcl-2.

Research topics

Cancer-related Molecular Pathways
Phytoestrogen effects and research
Genomics, phytochemicals, and oxidative stress

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.2174/1574892817666220321161318

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