article · Acta Crystallographica Section C Structural Chemistry
The highly cytotoxic macrocyclic trichothecene Isororidin A (C<sub>29</sub>H<sub>40</sub>O<sub>9</sub>) was isolated from the fungus Myrothesium verrucaria endophytic on the wild medicinal plant `Datura' (Datura stramonium L.) and was characterized by one- (1D) and two-dimensional (2D) NMR spectroscopy. The three-dimensional structure of Isororidin A has been confirmed by X-ray crystallography at 0.81 Å resolution from crystals grown in the orthorhombic space group P2<sub>1</sub>2<sub>1</sub>2<sub>1</sub>, with one molecule per asymmetric unit. Isororidin A is the epimer of previously described (by X-ray crystallography) Roridin A at position C-13' of the macrocyclic ring.
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DOI: 10.1107/s2053229624006144
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