Correlation between Serum Betatrophin Level and Histological Grading of Nonalcoholic Fatty Liver Disease

Abstract

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is recognized as the hepatic manifestation of metabolic syndrome frequently co-existing with obesity, dyslipidemia, and insulin resistance. It is characterized by hepatic steatosis in the absence of secondary causes such as significant alcohol consumption, chronic viral hepatitis, medications that induce steatosis, or other chronic liver diseases such as autoimmune hepatitis, hemochromatosis, or Wilson’s disease. NAFLD can be subcategorized into nonalcoholic fatty liver and nonalcoholic steatohepatitis (NASH). Aim of the Work to find out the role of Serum Betatrophin in predicting the presence of Nonalcoholic Fatty Liver Disease (NAFLD) and determining the correlation between Serum Betatrophin and Histological Grades of Nonalcoholic Fatty Liver Disease. Patients and Methods 90 Patient from Hepatology outpatient clinic in Ain Shams university hospital and Ahmed Maher Teaching Hospital was included in our study. The study population was assigned in two groups: Group A: Patient with biopsy proved NAFLD. Group B: Patient with healthy liver. Results In addition to Renal Function Test: Serum Creatinine & Blood Urea, Lipid Profile (Serum Cholesterol, TAG, LDL, HDL),Thyroid Function Test (TSH, FreeT3, FreeT4), FBS, PPBS, HbA1c%, Iron Profile (Iron, Ferritin) ceruloplasmin level, and serum Betatrophin Level. Pelviabdominal ultrasouography. Liver Biopsy using 16-G Non reusable Needle for group A was done. All the liver biopsy samples was include at least 10 total portal tracts and it was as long as 20 mm, stained with Haematoxlin & Eosin and Masson Trichome for histopathology. Conclusion NAFLD is a disease which occur more common in male and obese people. Patients with NAFLD may have low hemoglobin level low platelet count and reduced number of white blood cells. Liver function test such as liver enzyme, bilirubin level, Prothrombin concentration and Alpha Feto protein all are affected with NAFLD. Increase level of triglycerides is an independent risk factor in pathogenesis of NAFLD. Glycemic control and HBA1C level play a vital role in the occurrence of NAFLD also poor control of blood glucose lead to increase risk of NASH and progression to fibrosis.