Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study

Abstract

IntroductionPoor ovarian reserve (POR) is considered a serious condition that affects couples. There are different medical modalities and intervention trying to overcome POR. GH adjuvant therapy to ART is considered a promising drug. However, GH complications are not well studied.MethodsBetween 2021 to 2022. A prospective randomized control study, in which patients were divided into two groups, a study and a control group. Study group will receive an ICSI cycle with GH supplementation and control group.Results37 patients per group were included. Their mean age was 29.74± 5.88 years. The mean duration of infertility is also similar between the GH group (4.81 ± 2.16) and the control group (4.73 ± 2) with no significant difference between the groups (p = 0.86721). The average systolic blood pressure for the study group and the control group were 113 ± 20 ( 88 -135) and 110 ± 22 ( 87-130) mmHg respectively with no statistical significant difference ( p = 0.7412). The average random blood sugar mg/dl for the study group and the control group were 123±20 (90-140) and 119 ±24 ( 87-138) with no statistical significant different ( P= 0.6539). (Table 2) There were no cases with leg edema, added pain or change in overall features. ConclusionGH may have a positive role in POR undergoing ovarian stimulation. In addition, no sinister side effects of GH have been reported.