article · BIMA JOURNAL OF SCIENCE AND TECHNOLOGY GOMBE
Rising demand for sustainable and cost-effective excipients has led to interest in natural plant polysaccharides as substitutes for synthetic tablet binders. In this work, gums from Cissus populnea and Grewia mollis were extracted from local sources to assess their viability alongside paracetamol as a model active ingredient. Extraction delivered yields of 33.5 percent for Cissus gum and 32.3 percent for Grewia gum, exhibiting flow rates of 3.2 and 4.7 respectively. Physicochemical testing demonstrated promising flow properties for both materials. Compatibility evaluations using Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry revealed that neither gum altered the characteristic chemical peaks or thermal profiles of paracetamol. These results show that both natural gums are chemically and thermally compatible with the drug, offering potential as renewable, plant-derived binding agents for solid dosage formulations.
Pharmaceutical manufacturers typically rely on synthetic binders to hold tablets together. Identifying natural, plant-derived alternatives helps lower production costs while improving sustainability. Demonstrating that gums from local plants such as Cissus populnea and Grewia mollis are compatible with active medicines like paracetamol is an essential step toward developing safer, bio-based drug delivery systems.
This work could benefit pharmaceutical manufacturers seeking sustainable, bio-based excipients to replace synthetic binders in tablet production. The research remains at an early laboratory stage, having established extraction yields and chemical compatibility with a single model drug. Further formulation and tableting trials would be required before these gums could be integrated into commercial pharmaceutical processes.
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The increasing demand for sustainable, biocompatible and cost-effective pharmaceutical excipients has prompted the exploration of natural polysaccharides as alternatives to synthetic binders in tablet formulations. This study investigates the compatibility and suitability of two plant-derived gums, Cissus gum (from Cissus populnea) and Grewia gum (from Grewia mollis), as pharmaceutical binders for tablets, using Paracetamol as a model drug. Cissus and Grewia gums were extracted from local sources, and their yields and physicochemical properties were determined. Yield of 33.5 and 32.3% for Cissus and Grewia gums, and flow rate of 3.2 and 4.7 respectively are good physicochemical features. Compatibility with Paracetamol was assessed using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) to detect potential interactions. Results showed that both mixtures of model drug (PCM) and sample gums (Cissus and Grewia) did not alter the functional and characteristic peaks on FT-IR spectra and DSC thermograms, conferring compatibility. The findings of this study provide insights into the potential of Cissus and Grewia gums as eco-friendly, cost-effective alternatives in pharmaceutical tablet manufacturing, contributing to the development of sustainable excipients for drug delivery systems.
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DOI: 10.64290/bima.v9i3a.1347
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