Comparative evaluation of cerebellum development between Japanese quail and albino rats

Abstract

The surrounding environmental conditions are affected the cerebellum development among different vertebrates. In this study, we attempt to evaluate the differences in cerebellar histogenesis between Japanese quail and albino rats (post-hatching postnatal developmental assay). Four ages from each animal species (6 individuals for each age) were used in this study. These ages included 1, 7, 16, and 30 days for quail and 1, 7, 21, and 60 days for rats. The different age stages vary for each species. Blood samples were collected from sacrificed experimental animals to estimate the antioxidants. Then the animals were dissected to remove the cerebellum for histological and transmission electron microscope investigations. The histological results revealed that the cerebellar cortex of Japanese quail reaches full histogenesis before PHD-7, while the full histogenesis of the rat cerebellum occurs after PND-7. Likewise, the cerebellar cortex of rats showed obvious branching of folia with age progress if compared with that of the Japanese quail. Comparatively with Albino rats, the cerebellar cortex cells of Japanese quail showed remarkable myelination and lysosomes but less density of RER and mitochondria.