review · Catheterization and Cardiovascular Interventions

Comparative Efficacy and Safety of Low‐Dose Direct Oral Anticoagulants Versus Dual Antiplatelet Therapy Following Left Atrial Appendage Occlusion in Patients With Nonvalvular Atrial Fibrillation: A Systematic Review and Meta‐Analysis

Ahmed Ibrahim
Muhammed Elhadi
Pierre Sabouret
Mohammed S. Beshr
Laila Shalabi
Ghaith Y. Eljadid
Sohaila Mourad
Sofian Zreigh
Ali Abdelaziz
Shrouk Ramadan
Mamas A. Mamas

2025Open accessAlexandria University

Abstract

Low-dose DOACs effectively reduce thromboembolic events post-LAAO without increasing bleeding risk. These findings support their use as a viable ATT option, but larger trials are needed to confirm optimal regimens.

Research topics

Atrial Fibrillation Management and Outcomes
Cardiac Arrhythmias and Treatments
Antiplatelet Therapy and Cardiovascular Diseases

Sustainable Development Goals

Good Health and Well-being

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DOI: 10.1002/ccd.31461

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