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review · AIDS Research and Therapy

Clinical trials of broadly neutralizing monoclonal antibodies in people living with HIV – a review

202518 citationsOpen accessUniversity of Cape Town

Abstract

More recent trials that paired bNAbs with latency-reversing agents or combined multiple bNAbs demonstrated promising results, including delayed viral rebound and enhanced CD8 + T-cell responses. While bNAbs show potential as an adjunct or alternative to ART, obstacles such as viral resistance, high production costs, and scalability must be addressed. Continued research is crucial to developing more potent, durable, and affordable bNAbs for sustainable HIV treatment and potential remission.

Research topics

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • HIV/AIDS Research and Interventions

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DOI: 10.1186/s12981-025-00734-8

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