Clinical Characteristics and Patterns of Valve Lesions in Rheumatic Heart Disease Among Children at Hiwot Fana Comprehensive Specialized Hospital: A Comparative Study of Newly Diagnosed and Known Cases.

Abstract

<title>Abstract</title> <bold>Background:</bold> Rheumatic heart disease remains a significant health burden in resource-limited settings. This study investigates the clinical characteristics and valve lesion patterns of RHD in children from Eastern Ethiopia, comparing newly diagnosed and known RHD patients. <bold>Objective: </bold>This study aims to characterize the clinical features and valve lesion patterns in children with Rheumatic heart disease and provide a comparative analysis between newly diagnosed and known cases. <bold>Methods:</bold> A hospital-based cross-sectional study was conducted at Hiwot Fana Comprehensive Specialized Hospital from January 1 to December 31, 2021. A total of 39 children with RHD were included, with data collected from medical records, clinical assessments, and echocardiographic evaluations. Descriptive statistics and chi-square tests were used for analysis. <bold>Results: </bold>Among the 39 children studied, 25 were newly diagnosed and 14 were known RHD cases. The majority were female (71.8%). The median age was 10 years. Shortness of breath (53.9%) and cough (38.5%) were the most common presenting complaints. Only 14.3% of known RHD patients were adherent to secondary prophylaxis. Severe acute malnutrition and severe anemia were the most common comorbidities. Class IV heart failure was present in 89.7% of the patients. Echocardiographic findings revealed that all patients had mitral valve involvement, with mitral regurgitation (94.9%) being the most frequent. <bold>Conclusion: </bold>The study highlights significant clinical characteristics and valve lesion patterns among children with Rheumatic heart disease at Hiwot Fana Comprehensive Specialized Hospital, emphasizing the need for early diagnosis, improved adherence to prophylaxis, and targeted interventions to manage comorbidities and advanced heart failure.