article · Advances in Sample Preparation
Click analytical chemistry adapts principles from click chemistry to focus on simplicity, efficiency, and reliability in chemical analysis. To support this framework, the Click Analytical Chemistry Index provides an objective, practical metric alongside open-source software designed to assess and compare analytical methods. The tool bridges the gap between technical analytical performance and operational practicality, encouraging procedures that are straightforward to implement without compromising on analytical rigour. By offering an unbiased evaluation standard, the system enables users to benchmark different techniques effectively. Case studies demonstrate how this index and its accompanying software can be applied to real-world analytical procedures, guiding the development and selection of more efficient testing methods across chemical analysis.
Choosing the right chemical testing method often involves balancing technical accuracy with ease of use and operational efficiency. This index and its accessible software provide a standardised way to measure both aspects together. As a result, laboratories can more easily identify analytical procedures that are not only reliable and high-performing, but also simple, efficient, and practical to operate on a daily basis.
The framework is implemented as an open-source software tool, making it directly accessible to analytical chemists, quality control specialists, and laboratory managers. It facilitates the benchmarking and selection of chemical analysis methods. Based on the abstract, the software is already developed and supported by real-world case studies, placing it at an applied and tested stage for immediate adoption in method evaluation.
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• A new assessment tool supported by open-source software for method evaluation. • CACI emphasizes simplicity, efficiency, and practical aspects in chemical analysis. • This tool provides an objective metric for comparing analytical methods. • Case studies demonstrating real-world applications are discussed. • CACI bridges the gap between analytical performance and practical attributes. Click analytical chemistry (CAC) is a novel approach inspired by the principles of click chemistry, emphasizing simplicity, efficiency, and reliability. While click chemistry revolutionized synthetic methods, CAC aims to enhance chemical analysis by providing a framework for method assessment from a different perspective, focusing on improving the practicality and applicability of analytical techniques. In this work, we present the Click Analytical Chemistry Index (CACI) as a practical and user-friendly tool that provides both a metric and software solution for evaluating analytical methods. The software is available as an open source at bit.ly/CACI2025 . The CACI system allows for objective and unbiased comparisons between techniques, encouraging the development of methods that are easier to implement without sacrificing performance. By promoting simplicity and practicality in method design, CACI supports the development of analytical procedures that not only meet rigorous performance standards but also simplify the analytical process. This work explores the principles and methodology of CAC and presents case studies that demonstrate its practical applications in advancing chemical analysis towards more efficient method development and evaluation.
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DOI: 10.1016/j.sampre.2025.100164
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