Chemical composition and antidermatophytic propriety of Spermacoce ocymoides and Deutarium microcarpum leaves essentials oil harvested in cameroon

Abstract

Fungal infections constitute a serious public health concerned due to the development of resistance to therapy. To better manage this problem, the use of botanical extracts such as essential oils is one of the alternative tools. Therefore, the aim of the present study is to evaluate the chemical composition and the antidermatophytic activity of S. ocymoides and D. microcarpum leaves essential oils extracts on fungal strains. Fact, the chemical composition of the investigated essential oils was determined both by chromatography/flame ionization detector and gas chromatography/mass spectrometry methods while the antidermatophytic activity on 5 dermatophytes strains was performed using the solid medium diffusion method. The obtained results showed that the chemical composition and antidermatophytic activity of the two essential oils varied significantly according to plant species. However, 27 compounds were identified in S. ocymoides essential oil with Cubitene (50.34 %), Thiazole (15.52 %) and α-cendrene (6.43 %) as major components while 47 constituents were found in D. microcarpum with Pentenol (36.38 %), Evodione (11.04 %) and γ-bibosalene (5.08 %) being the most abundant. Antidermatophytic activity evaluation showed that all fungi tested were inhibited by these two studied essentials oils. The S. ocymoides essential oil was more active than griseofulvin against the dermatophytes studied with MICs and MCFs of 75 µL/L against E. floccosum . D. microcarpum essential oil activity against M. audouinii was similar to griseofulvin at 250 µL/L. S. ocymoides essential oil was the most efficient against dermatophytes and can be used in the formulation of new antifungal drugs. • The two essential oils contain a lot of chemical components. • These two essential oils are anti-dermatophytic. • S. ocymoides essential oil is more effective than griseofulvin. • D. microcarpum essential oil against Microsporum audouinii was similar to griseofulvin.