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Characterization of near-complete human <i>Pegivirus</i> 2 (HPgV-2) genomes in individuals co-infected with hepatitis C virus (HCV) in Cameroon

Aristide Mounchili-Njifon
Janin Nouhin
Jean Paul Assam Assam
Leakhena Pum
Abdou Fatawou Modiyinji
Pretty Rosereine Mbouyap
Moise Henri Moumbeket-Yifomnjou
Desmon Toutou Toutou Tsafack
Simon Frédéric Lissock
Loique Landry E. Messanga
Vireak Heang
Ladifatou Nzi Mbouo-Njoya
Erik A. Karlsson
Richard Njouom

2026Open accessUniversité de Yaoundé I

Abstract

Human <i>pegivirus</i> (HPgV) genomes were detected in HCV-infected plasma via nanopore metagenomics. Six nearly complete HPgV-2 genomes were identified. Phylogenetic analysis confirmed HPgV-2 genotype. This study reveals co-infection dynamics, highlights viral diversity, and supports improved diagnostics.

Research topics

Hepatitis C virus research
Animal Virus Infections Studies
Respiratory viral infections research

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1128/mra.00069-26

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