article · Preparative Biochemistry & Biotechnology
Researchers have synthesised silver nanoparticles using leaf extract from the plant Petiveria alliacea. Characterisation confirmed the particles are monodispersed and crystalline, with sizes ranging between 16.70 and 33.74 nanometres, coated with plant-derived phenolic compounds and proteins. In laboratory evaluations, the nanoparticles demonstrated complete inhibition against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. They also displayed strong antifungal effects, achieving complete inhibition against Aspergillus fumigatus and Aspergillus flavus at tested concentrations, as well as partial inhibition against Aspergillus niger. Furthermore, the nanoparticles exhibited marked antioxidant properties, scavenging DPPH and hydrogen peroxide free radicals, and prevented the coagulation of human blood. These combined characteristics indicate potential utility across various biomedical applications.
Plant-based synthesis offers an eco-friendly route to produce functional nanoparticles without harsh chemicals. Demonstrating that Petiveria alliacea leaf extract can generate silver nanoparticles with potent antibacterial, antifungal, antioxidant, and anticoagulant activities provides a scientific foundation for developing natural agents to combat infectious microbes and oxidative stress.
The findings suggest potential applications for developers of antimicrobial treatments, wound-care products, or anticoagulant formulations. However, because the abstract reports only early-stage laboratory characterisation and in vitro testing, the technology remains at a preliminary research level. Significant formulation development, safety evaluation, and clinical validation would be required before real-world biomedical deployment.
AI-generated from the published abstract. Always read the original work before citing.
Phytosynthesis of silver nanoparticles (AgNPs) using leaf extract of Petiveria alliacea (PA) was the focus of this research work. The PA-AgNPs were characterized by UV–Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and selected area electron diffraction (SAED) study. Studies were made on the AgNPs for antibacterial, antifungal, anticoagulant, free-radical scavenging, and hydrogen peroxide scavenging activities. The crystalline PA-AgNPs were monodispersed, with a size range of 16.70–33.74 nm and maximum absorption at 410 nm. FTIR analysis displayed prominent peaks at 3430.6, 1711.8, and 1165.9/cm, which showed the existence of phenolic compounds and proteins in the synthesis of AgNPs. PA-AgNPs was active against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, with 100% inhibition. The PA-AgNPs also displayed good antifungal properties, as the concentrations of 100 and 150 µg/mL had 100% inhibition toward Aspergillus fumigatus and Aspergillus flavus. However, there was 66.67% inhibition of Aspergillus niger. It scavenged both DPPH and H2O2 by 70.69 and 89.02%, respectively. PA-AgNPs also prevented the coagulation of human blood. This study, being the first of its kind to use the leaf extract of PA for the synthesis of AgNPs has shown that PA-AgNPs can find biomedical applications.
This page summarises published work. The authoritative version sits with the publisher.
DOI: 10.1080/10826068.2018.1479864
Is something wrong with this record? Report it or request removal.
Discussion
Have you built on this work, tried to replicate it, or seen it applied in practice? Share what you know. Verified researchers and MARATTO™ domain experts can open a discussion, and any member can reply. Contributions are reviewed before they appear.
No discussion yet. Open the first thread.
New to MARATTO™? Create a free account.
