review · ecancermedicalscience
CSC-driven recurrence is a multifaceted and dynamic process shaped by epigenetic, transcriptional, metabolic and immunologic adaptations. Single-target strategies are unlikely to achieve durable eradication. Future research must prioritise multi-targeted approaches, integrate CSC endpoints into clinical trials and develop predictive biomarkers of CSC burden. Addressing CSC-mediated relapse is essential for advancing precision oncology and achieving lasting therapeutic responses.
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DOI: 10.3332/ecancer.2025.2016
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