Brain Structure of South African Children Born to Mothers on Dolutegravir versus Efavirenz-Based Antiretroviral Therapy

Abstract

Among this small sample of children at 3-4 years, statistically significant differences in global or regional brain structure were not detected between those exposed in the third trimester of pregnancy to DTG or EFV and CHU. Given the modest sample size, the study had limited power to detect small-to-moderate differences. Further longitudinal studies with larger sample sizes are needed to assess the effects of specific ART in the context of new regimens and better maternal HIV disease control, on CHEU brain structure.