article · Journal of Enzyme Inhibition and Medicinal Chemistry

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR WT and EGFR T790M inhibitors

Tarfah Al‐Warhi
Taghreed A. Majrashi
Ahmed Nabil
Ahmed A. Al‐Karmalawy
Maha A. Alshubramy
Marwa Abdel‐Motaal
Wagdy M. Eldehna
Ayman Abo Elmaaty
Medhat Asem
Marwa Sharaky

202248 citationsOpen accessBadr University in Cairo

In plain language

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Abstract

were assessed for their EGFR kinase (Wild and T790M) inhibitory activities, revealing eligible potential. Additionally, molecular docking, ADME, and SAR studies were carried out for the investigated candidates.

Research topics

Synthesis and biological activity
Computational Drug Discovery Methods
Synthesis and Characterization of Heterocyclic Compounds

Sustainable Development Goals

3Good Health and Well-being

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DOI: 10.1080/14756366.2022.2135512

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