article · Future Medicinal Chemistry
Both diastereoisomers <b>3</b> and <b>4</b> demonstrated superior activity compared to standard drugs. Compound <b>3</b> showed potent α-amylase inhibition IC<sub>50</sub> = 22.78 µM) compared to Acarbose IC<sub>50</sub> = 123 µM). For antioxidant activity, compounds <b>4</b> and <b>3</b> exhibited strong DPPH scavenging IC<sub>50</sub> = 68.16 and 79.50 μM, respectively), outperforming ascorbic acid. Docking studies confirmed favorable binding interactions within the active sites of target enzymes. The synthesized oxadiazolo-benzodiazepines represent promising multifunctional antidiabetic and antioxidant candidates, warranting further pharmacological investigation.
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DOI: 10.1080/17568919.2026.2636823
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