Bioactive Effects of Ginger and Black Seed Oils on Male Rat Fertility

Abstract

Open Access*Corresponding author: Haggag M HamdyEmail: Mohamed.Hamdy@heco.helwan.edu.egMobile +20102313909Received: 2 Desember2024Accepted: 20 December 2024 Published online: 31 Dezember 2024 Citation:Hussein AA; Ziada MS; Hassan ST and Haggag M Hamdy (2024): Bioactive Effects of Ginger and Black Seed Oils on Male Rat Fertility. BNNI (64) 235-264. doi:10.21608/bnni.2024.402671This study was carried out to investigate the bioactive effects of ginger and black seed oils on the fertility of male rats. Thirty albino rats of the Sprague-Dawley strain were randomly distributed into 5 groups, the 1st group (6 rats) was fed the basal diet as negative control (-ve). The 2nd group received lead acetate (60mg/kg bw.) orally by gavage three times per week to induce infertility and served as +ve control. Groups 3, 4, and 5 were the same as group 2 but fed on a basal diet containing 5% ginger, 5% black seed oils, and 2.5% of each oil, respectively. Fatty acid content and total phenolic content of both oils were estimated. At the end of the experimental period (8 weeks), feed intake, body weight gain, and feed efficiency ratio were calculated. Sex Organs (spermatogenic cells) were collected for histological examination. Lipid profiles, Testosterone, malondialdehyde, and catalase were determined. The results indicated that ginger had the highest value of saturated fatty acids and phenolic content compared to black seed oil but black seeds had higher values of unsaturated fatty acids. Tested oils caused a significant reduction of TC, LDL-c, VLDL-c, and MDA. On the contrary, there was a substantial increase in catalase compared to the +ve control group. It could be concluded that ginger and black seed oils have a potential effect on fertility therefore, this study recommends increasing the dietary intake of ginger and black seed oils because these oils may be beneficial for patients with low fertility.