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article · Vox Sanguinis

Autoantibodies to ADAMTS13 in human immunodeficiency virus‐associated thrombotic thrombocytopenic purpura

Abstract

The metalloprotease, cysteine-rich and spacer domains are the primary targets for anti-ADAMTS13 IgG autoantibodies in patients with HIV-associated TTP. These findings suggest potential effects on the proteolytic activity of ADAMTS13, highlighting the complex nature of the pathogenic mechanisms involved.

Research topics

  • Complement system in diseases
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Trypanosoma species research and implications

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DOI: 10.1111/vox.13738

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