Association of vitamin D receptor TaqI gene polymorphism and vitamin D deficiency with risk of pulmonary tuberculosis in the Ethiopian population

Abstract

Background: gene polymorphism and vitamin D deficiency affect the risk of developing pulmonary tuberculosis. Methods: A hospital-based case-control study of 70 pulmonary tuberculosis patients and 70 age- and sex-matched healthy controls was conducted. Serum 25-hydroxyvitamin D levels were measured using ELISA to assess vitamin D status. Genomic DNA was extracted from peripheral blood samples, and VDR TaqI polymorphism was analyzed using PCR-RFLP. Data were analyzed using independent t-tests, chi-square tests, and multivariable logistic regression to calculate adjusted odds ratios at a 95% confidence level. Results: < 0.001), indicating that it is a major risk factor for the onset of pulmonary tuberculosis. Conclusion: gene of the tt genotype and the t allele have been linked to an increased risk of developing pulmonary tuberculosis. Moreover, vitamin D deficiency is a risk factor for the occurrence of pulmonary tuberculosis.