Assessment of the Prospective Protection of Quercetin on Irradiated Submandibular Salivary Gland in Mice

Abstract

Abstract Objectives This study aimed to assess the prospective protection of quercetin on irradiated submandibular salivary gland in mice histologically and immunohistochemically. Material and Methods Four groups of male mice were included in the study. Group included 10 mice that will not be subjected to gamma radiation, group included 10 mice that will receive quercetin 50 mg/kg body weight (BW) for 30 days, group included 10 irradiated mice that will receive a dose of only 15 Gy, and group IV included 10 irradiated mice that will be given quercetin 50 mg/kg BW for 30 days prior to radiotherapy. Results The analysis of variance (ANOVA) test revealed that the difference between all groups was extremely statistically significant (p < 0.000). Turkey's post hoc test revealed that there were no statistically significant differences between groups I and II but both groups showed statistically significant differences with groups III and IV. Also, there were statistically significant differences between groups III and IV. Conclusion Quercetin possesses the ability to protect against radiation-induced cellular damage and maintain tissue integrity, so it holds promise as a protective agent for salivary glands against radiation-induced damage. Quercetin has promising potential therapeutic benefits for individuals undergoing radiation therapy.