Assessment of H. pylori seropositivity in Multiple sclerosis and its relationship with disease severity in Egypt

Abstract

Background: Studies have shown that H.Pylori might have a protective role in Multiple Sclerosis MS. However, there are inadequate and inconsistent epidemiological data regarding H. pylori serology among MS patients in Egypt. Objectives: We aim to measure and analyze the serum level of IgM and IgG of H. pylori among different clinical subsets of MS and to correlate it with the number of relapses, duration of disease, Disease Modifying Therapy DMT and Expanded Disability Status Scale EDSS. Methods: This is a case-control study that included 22 patients with SPMS secondary progressive multiple sclerosis and RRMS relapsing remitting multiple sclerosis and 22 control are recruited. The study comprised patients with a confirmed diagnosis of MS in accordance with the 2017 revisions to McDonald's criteria. Results: H. pylori immunoglobulin M IgM and IgG seropositivity in cases and control groups showed no significant difference among both groups. Conclusion: There was an insignificant association between the H. pylori antibodies and MS. Studies with a larger sample size are required to support our findings even more.