Assessment And Follow Up of Renal Function in Patients With Common Types Of Mucormycosis

Abstract

Background: Mucormycosis is an infrequent illness, even in high-risk cases, and accounts for 8.3%-13% of all fungal infections found in such individuals. This study aimed to assess and follow up on the renal function in patients with common types of mucormycosis in two central hospitals at Sharqia Governorate (Zagazig University Hospitals and El Ahrar Educating Hospital).Subjects and methods: A Cohort study was conducted on 36 patients with mucormycosis which was confirmed or suspected infection based on EORTC/MSG parameters by a positive Mucorales quantitative polymerase chain reaction (qPCR). Patients were categorized into three groups: 36 Patients admitted with a diagnosis of mucormycosis in the two hospitals were divided into three groups: Group 1: 12 Patients with normal kidney function. Group 2: 12 Patients with elevated serum creatinine on conservative treatment. Group 3: 12 Patients with renal failure (on regular hemodialysis). All cases were conducted to complete history taking, clinical assessment, laboratory, and radiological examination.Results: There was a highly significant difference between groups regarding Lymph count, albumin, random blood sugar, and HbA1C (0<0.001). Also serum creatinine, blood urea nitrogen, urea, K, Ca, Ph, PT, and sodium level on admission, Middle time (3rd to 4th months from start of the study), and Last time (5th and 6th months) differed significantly between the groups (P<0.05). Conclusion: Infection with mucormycosis is associated with a risk factor that is renal impairment or failure. Additionally, renal function affects the prognosis of the disease, which is described as morbidity and mortality.