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article · Frontiers in Immunology

AS01B-, MF59-, and alum-based adjuvants and HIV vaccine immunogenicity: a post-hoc cross-protocol comparison of results from HVTN 100, 107, 120, and 702

Abstract

The AS01<sub>B</sub> adjuvant demonstrated superior IgG binding antibody and CD4+ T-cell responses compared with MF59 and Alum, when given with gp120 protein boost after ALVAC-HIV prime. These findings support AS01<sub>B</sub> as a superior adjuvant for HIV vaccine development, relative to MF59 and Alum.

Research topics

  • HIV Research and Treatment
  • Immunotherapy and Immune Responses
  • HIV/AIDS drug development and treatment

Sustainable Development Goals

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DOI: 10.3389/fimmu.2026.1768201

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