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article · Acta Parasitologica

Appraisal of Chitosan-Coated Lipid Nano-Combination with Miltefosine and Albendazole in the Treatment of Murine Trichinellosis: Experimental Study with Evaluation of Immunological and Immunohistochemical Parameters

20248 citationsOpen accessMenoufia University

Abstract

Loading ABZ or MFS on chitosan-coated NLCs enhanced their efficacy against trichinellosis. Although ABZ was better than MFS, their combination should be considered as MFS caused a significant reduction in the intensity of infection. Furthermore, MFS showed anti-inflammatory (↓GATA3) and antiapoptotic effects (↓caspase-3), especially in the muscular phase. Also, when loaded with NLCS, it showed an antioxidant effect (↑GPX1).

Research topics

  • Parasitic Diseases Research and Treatment
  • Parasite Biology and Host Interactions
  • Parasites and Host Interactions

Sustainable Development Goals

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DOI: 10.1007/s11686-024-00799-x

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